KMID : 0604520230490020141
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Journal of the Society of Cosmetic Scientists of Korea 2023 Volume.49 No. 2 p.141 ~ p.146
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Simple and Efficient Method for the Enantiomeric discrimination of Racemates
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Rho Ho-Sik
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Abstract
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The efficient use of a chiral shift agent (3) containing bifunctional group (thiourea and tertiary amine) for the determination of the enantiomeric purity of racemic mixture (Hemiesters) has been studied. The diastereomeric complexes derived from a chiral shift agent (3) with various hemiesters gave rise to well separate signals of the methoxy protons of hemiesters. Good splitting signals for enantiomers of hemiesters in 1 H NMR are originated form the hydrogen bonds between carbonyl groups of hemiester and bifunctional groups of a chiral shift agent (3) such as thiourea moiety and tertiary amine. This study provides a quick and simple way to determine the chiral purity of hemiester using chiral transfer agent (3).
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KEYWORD
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chiral shift agent, thiourea, tertiary amine, hemiesters
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